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KMID : 0377819980180060652
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Diagnosis and Treatment
1998 Volume.18 No. 6 p.652 ~ p.659
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IMPACTS OF ADDED PROGESTOGEN ON BIOCHEMICAL MARKERS OF THE BONE TURNOVER UNDERGOING HORMONE REPLACEMENT THERAPY IN POSTMENOPAUSAL WOMEN
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Abstract
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Purpose To evaluate the impact of added progestogen on biochemical markers of the bone turnover undergoing hormone replacement therapy in the postmenopausal women. Method : There are 71 postmenopausal women who are divided into three groups (Group I, Group II, Group III). Group I(continuous combined) is given conjugated equine estrogen WEE, 0.625mg, day 1-30) plus medroxy-
progesterone acetate (MPA, 2.5mg, day 1-30), Group II(unopposed estrogen) is given conjugated equine estrogen(CEE, 0.625mg, day 1-30) only, Group III(continuous sequence) is given conjugated equine estrogen(CEE, 0. 625mg, day 1-30) plus medroxyprogesterone acetate (MPA, 5mg, day 1-12). And there were measured serum osteocalcin, serum total alkaline phosphatase and urinary deoxypyridinoline excretion before starting hormone replacement therapy and 12 months later. Results : The serum osteocalcin, serum total alkaline phosphatase and urinary deoxypyridinoline excretion significantly decreased after hormone replacement therapy (Group I, II, III). And there was no significance
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KEYWORD
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